retatrutide trial weight loss results VisualAbstract: reduces body by 17.5% in patients with obesity Retatrutide phase 3 obesity trial

Supplements may help modestly and require caution

When You Should Use the Longer (3-Month or More) Timeline Stick with the conservative 3-month approach if youre under 35 and have time to be conservative, youve had extended GLP-1 use (on medication for 6+ months), your baseline cycles were irregular before starting medication (especially with PCOS), youve had significant weight loss (50+ pounds) and need more time for metabolic stabilization, you need time to transition to pregnancy-safe diabetes medications and optimize glucose control, or you have a history of miscarriage and want to optimize conditions

Key highlights Semaglutide is a popular and effective GLP-1 receptor agonist manufactured by Novo Nordisk

The titration schedule over 16-20 weeks allows the body to adapt gradually