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Evidence of a hepatoprotective effect also exists for exenatide: this drug has been evaluated in several randomized clinical studies involving T2DM and obese patients and was shown to reduce liver enzymes, hepatic fat content, hepatic triglyceride content, and epicardial fat [78,79,80]

Perspective RWS confirm the transferability of results seen in RCTs to populations less represented in these trials, such as the elderly or non-obese individuals or those with diabetic kidney disease

Losing this much weight may not be realistic over the long-termwith either medications, lifestyle changes, or even surgery

When that data is missing or delayed, regulators cannot make fully informed decisions about a drugs safety profile