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The compound's ability to reduce pro-inflammatory cytokines, repair mitochondrial dysfunction, and restore epidermal barrier integrity makes it particularly suited for therapeutic creams and ointments targeting chronic skin conditions

Xiang, Q

On the other hand, during the process of reactive astrogliosis, astrocytes release inflammatory cytokines that may affect the surrounding neurons, both by the induced production of ROS and lipid peroxidation, and by the activation of apoptotic mechanisms that induce neuronal dopaminergic death [6,10]

428 Campanella found that frataxin knockout in yeast could maintain mitochondrial DNA integrity and restore mitochondrial respiratory ability, and FtMt overexpression protected cells from oxidative stress caused by H 2 O 2 treatment