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Endocrine 75 (3), 672683

These are unused, unburned calories being held in reserve because the intake of calories consumed exceeded calories burned

(Thng 12 nm 2021)

And since tirzepatide works with a similar mechanism of action and is showing even greater reduction in weight and A1c (a marker of diabetes), tirzepatide will likely show a similar benefit, but trials are still ongoing since the drug is newer to the market, she says