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Predicting islet cell autoimmunity and type 1 diabetes: an 8-year TEDDY study progress report

3 Cellular signaling pathways of butyrate 3.1 G protein-coupled receptors (GPCRs) Butyrate is the ligand for metabolite-sensing G-protein coupled receptors (GPCRs), mainly GPR43, GPR41, and GPR109a (100), which are also known as free fatty acid receptors 2 (FFAR2), free fatty acid receptors 3 (FFAR3), and Hydroxy-carboxylic acid receptor 2(HCA2), respectively (101, 102)