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And they are also "artificial, Western innovations", which doesn't help This is a post Ive been intending to write for a very long time now, but been putting off for one reason or the other

Hepatic overexpression of SIRT6 inhibits intestinal cholesterol and fat absorption and reduces very low-density lipoprotein secretion, providing protection against steatohepatitis and atherosclerosis induced by a Western diet in Ldlr / mice [14]