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Impaired cognitive function : Dehydration can affect cognitive function, leading to difficulties with concentration, memory, and overall mental performance Increased risk of heat-related illnesses: Chronic dehydration can make individuals more susceptible to heat exhaustion and heatstroke

Muscle loss requires individual protein and training targets, assessed against actual lean mass rather than a generic guideline

NAC activates cystine-glutamate antiport transporters present in astrocytes, leading to the release of glutamate that stimulates extra-synaptic metabotropic receptors (mGluRs), thereby reducing the synaptic release of the neurotransmitter (Baker et al., 2002

As a transcription factor, NRF2 activity and stability are regulated by various PTMs and epigenetic modifications, which directly influence NRF2s transcriptional activity and function