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In this narrative literature review, we explore the pharmacological properties of tirzepatide and critically summarize and comment on the results of the clinical studies conducted thus far, as well as discuss the potential implications for the treatment of obesity, T2DM, and associated cardiometabolic complications

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It is an oral, gut-restricted peptide (never reconstituted or injected), and it remains investigational: its Phase 3 celiac program was discontinued in 2022 for missing its endpoint