PMCID: PMC7540535 ) Elashoff M, Matveyenko AV, Gier B, Elashoff R, Butler PC (2011) Pancreatitis, pancreatic, and thyroid cancer with glucagon-like peptide-1-based therapies
Possible Clinical Consequences: Elevated TSH levels Fatigue, weight gain, cold intolerance Persistent or worsening hypothyroid symptoms Pharmacist Counseling Tip: Advise patients to take thyroxine early morning on an empty stomach, with water only, and maintain a minimum 4-hour interval before consuming calcium or iron supplements
For weight management, treatment typically requires at least 612 months, with NICE recommending discontinuation if less than 5% weight loss is achieved after 6 months (Wegovy) or 12 weeks (Saxenda) at maintenance doses
The biggest risk factor is taking more than prescribed or using it for non-medical reasons