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The new 5-HT hypothesis of depression: cell-mediated immune activation induces indoleamine 2,3-dioxygenase, which leads to lower plasma tryptophan and an increased synthesis of detrimental tryptophan catabolites (TRYCATs), both of which contribute to the onset of depression

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Hormone optimization Imbalances in thyroid, cortisol, or insulin can make weight loss extremely difficult

Glutathione cycles continuously between its reduced and oxidized forms, but it's also vulnerable to enzymatic breakdown in the gut