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Drug Interactions The concomitant use of SYNJARDY or SYNJARDY XR with specific drugs may increase the risk of metformin-associated lactic acidosis: those that impair renal function, result in significant hemodynamic change, interfere with acid-base balance or increase metformin accumulation [see DRUG INTERACTIONS ]

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For example, at the time of the study, of those using GLP - 1 drugs for longer than one year, more than three-quarters said they were using the drug for health management, and less than one-quarter for weight loss