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In the STEP 1 trial, nausea, diarrhoea, vomiting or constipation affected around 74% of people on semaglutide, compared with about 48% on placebo, and a small number stopped treatment because of side effects

Perkins says, are often the best candidates for a lower dose. But any dose adjustment should be supervised by a licensed physician

While drugmakers work to reduce side effects and improve affordability, consumers continue driving a broader transformation of the grocery and health retail landscape