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Exendin-4 also engages the GLP-1R in a comparable manner, with the ECD adopting a similar conformation to the GLP-1-bound receptor (Figure 3A)

This review will focus on recent findings describing how different pathological states compromise BBB integrity, discuss current potential therapeutic approaches that have been explored for improving BBB integrity and slowing neurodegenerative disease pathologies, and the recent findings in microbial mediated modulation of the BBB

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