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doi: 10.3389/fendo.2020.00288 Received 10 December 2019 Accepted 16 April 2020 Published 05 June 2020 Volume 11 - 2020 Edited by Claire Joanne Stocker, University of Buckingham, United Kingdom Reviewed by Edward Wargent, University of Buckingham, United Kingdom

But scientists dont yet know how much that matters in practice

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The current evidence base nevertheless remains constrained, as mechanistic insights are derived largely from animal and in vitro studies, clinical investigations are typically small and cross-sectional, and well-powered longitudinal cohorts are scarce (Table S2)