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If you're talking about blood sugar and fullness signals and all that, it makes sense that you're doing it with meals, although I could see why people might think doing it between meals could have its own positive effect of potentially reducing your hunger signals, for example

Retatrutide is an investigational once-weekly injectable triple receptor agonist that simultaneously activates GLP-1, GIP, and glucagon receptors to reduce appetite, increase energy expenditure, and improve metabolic function