Unimolecular peptides with dual GIP/GLP-1 receptor agonism have been developed to improve metabolic efficacy and therapeutic index beyond what incretin mono-agonists can achieve (44, 63)
A Remotely Delivered GLP-1RA-Supported Specialist Weight Management Program in Adults Living With Obesity: Retrospective Service Evaluation
In addition, intra-VTA application of exendin-4 suppresses high-fat food intake, which is consistent with the results of chemogenetic activation of endogenously released GLP-1 nerve terminals in the VTA (Wang et al., 2015)
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