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2022;17(6):e0269698

As shown in Figure 4F , the transcriptional levels of IL-21 and IFNG in the L-Cn-treated groups were significantly lower than those in the control groups in both Jersey and Holstein cattle, which were consistent with the results of the available in vitro experiments, while the transcripts encoding immunosuppressive profiles, such as myeloid-derived suppressor cells ( CD33 ), arginase-1 ( Arg1 ), and inhibitory receptors ( PD-L1 , CTLA4 , and HAVCR2 ) were higher in the L-Cn-treated groups

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147 Activation of insulin signaling pathway PI3k/Akt leads to Ser9 phosphorylation of GSK3 and its impaired kinase activity leads to phosphorylation of tau