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Research Studies Demonstrating Side Effects A 2021 double-blind, placebo-controlled study in the New England Journal of Medicine evaluated overweight or obese patients taking once-weekly semaglutide 2.4 mg and compared them to patients taking placebo

Medication-specific pharmacokinetics also matter

It is also possible that differences in population, trial design, and dose will result in numbers lower than retatrutide's Phase 3 data

Early-stage clinical trials have produced unprecedented weight-loss results, eclipsing even the massive success of semaglutide (Ozempic) and tirzepatide (Mounjaro)