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Pharmaceutical R&D returns for the world's top 20 pharma companies have improved for a third consecutive year to 7%, thanks almost entirely to a handful of high-forecast assets such as glucagon-like peptide receptor agonists, or GLP-1s

GLS expression is increased post-castration in LNCaP and LAPC4 xenografts (61), and pharmacological inhibition of GLS1 reduces the tumor burden in PC3, but not LNCaP xenografts (61), highlighting the dependency on glutamine metabolism in AR-negative, hormone-insensitive prostate cancer (61)

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Abnormal, unexpected, or conflicting results should be reviewed with a qualified healthcare provider