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Underlying Health Conditions Some medical conditions may influence or worsen melasma: Thyroid Issues: An imbalance in thyroid hormoneseither hypo- or hyperthyroidismcan increase susceptibility to melasma

[DOI] [PubMed] [Google Scholar] 17.Wang C., Ye Y., Hochu G.M., Sadeghifar H., Gu Z

however, in the context of retatrutide's triple-agonist design, this effect is counterbalanced by the concurrent GLP-1 and GIP activity, resulting in a net improvement in glycaemic control

Inflammatory Conditions: Skin inflammation or injury, such as acne scars or eczema, can trigger abnormal melanin production, resulting in post-inflammatory hyperpigmentation