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Description

REST directly binds to the promoter region of glutamate-cysteine ligase (GCLM), inhibits the synthesis of GSH through transcriptional inhibition of GCLM expression, and induces ferroptosis

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Dose requirements : How much is needed to achieve therapeutic results

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There are various causes, including excess melanin production

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Treatment of infantile-onset spinal muscular atrophy with nusinersen: final report of a phase 2, open-label, multicentre, dose-escalation study

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