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WADA Prohibition The World Anti-Doping Agency classifies both peptides as prohibited substances for competitive athletes: Section S2 classification Peptide Hormones, Growth Factors, and Related Substances Prohibited at all times (both in-competition and out-of-competition) No Therapeutic Use Exemptions available not recognized as legitimate medical treatments Performance-enhancing potential acknowledged due to growth hormone secretagogue effects Detection methods under development for anti-doping testing programs WADAs position reflects that these peptides possess clear performance-enhancing properties and lack approved therapeutic applications that would justify medical use exemptions

3.3 Evaluation of cytokines and chemokines in tears during clinical study As detailed in the materials and methods section of the manuscript, the concentration of different cytokines and chemokines in tears was analyzed using flow cytometry at four study visits following randomization: V1, V3 (1 month after the initial control or the experimental formulation treatment), V4 (after the 1-week wash-out), and V6 (1 month after the crossover treatment)

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