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Metformin, a medication for individuals with type 2 diabetes mellitus, was found to decrease vitamin B 12 absorption possibly by tying up free calcium required for absorption of the IF-B 12 complex (143)

Deficiency of vitamin D could contribute to increased activity of the renin-angiotensin system and an increased risk of hypertension

Therefore, translating SSS-based circular economy concepts into tangible sustainability outcomes will require applications with proven scalability and promising laboratory findings toward pilot- and field-scale validation (Table 4)