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Very few address the shared upstream driver: a chronically overactivated stress-hormone system that simultaneously blocks restorative sleep and rewires metabolism toward fat storage and glucose dysregulation

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[DOI] [PubMed] [Google Scholar] 119.Lien T.S., Sun D.S., Chang C.M., Wu C.Y., Dai M.S., Chan H., Wu W.S., Su S.H., Lin Y.Y., Chang H.H

Animal Model:8-10 male C57BL/6J mice [1] Dosage:50 mg/kg Administration:i.p., a single dose for 28 or 12 days Result:Displayed a more oxidative muscle phenotype, increased the complex I (NDUFB8) and complex V (ATP5A) protein expression in the gastrocnemius muscle and cytochrome C, mitochondria content and oxidative type IIa muscle fibers lavels in mice