While GLP-1 medications like Ozempic, Wegovy and Zepbound were originally developed to treat type 2 diabetes, their use for weight loss has surged globally, along with scrutiny around who should be promoting them
3 Macrophage polarization and immunometabolism The functional states of macrophages are not only regulated by microenvironmental inflammatory signals, but are also closely associated with dynamic reprogramming of intracellular metabolic networks, thereby exhibiting a high degree of plasticity
However, given the presence of GLP-1R in the ARC and the direct contact of the ARC with the circulation, it is plausible that GLP1-RAs could have a direct effect on the hypothalamus, on the proviso that GLP-1RA levels exceed physiological levels of GLP-1
with monthly dosing, there was continued weight loss and at 60 weeks at the highest dose (4.8 mg monthly) there was 15% weight loss from baseline, Buse said during the presentation
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