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Description

This reaction simultaneously depletes two critically important metabolic cofactors: SAM (the universal methyl donor for hundreds of epigenetic and biosynthetic reactions) and nicotinamide (the precursor for NAD+ biosynthesis via the salvage pathway)

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In obesity management, conventional interventions, such as lifestyle modification and traditional pharmacotherapy, demonstrate limited efficacy in patients with moderate to severe obesity, and sustained weight loss is difficult to achieve

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This may have contributed to individuals presenting at a relatively late stage in their disease course

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NICE recommends semaglutide 2.4mg (Wegovy) for a maximum of 2 years on the NHS within specialist weight management services

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