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These cases demonstrate the utility of GLP-1 agonists in treating dermatologic conditions that are refractory to other therapies and further highlight the potential of GLP-1 agonists in treating skin disease

N Engl J Med 2016;375(8):794798;

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Further mechanistic studies have found that treatment with TMZ promoted cardiac Nrf2 expression, indicating that TMZ enhanced the clearance of oxidative stress by activating the GSH system through the Nrf2 signaling pathway [210]