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GSH and GPX4 form a defense system against the increase of lipid peroxides

Hodges RE, Hood J, Canham JE, Sauberlich HE, Baker EM

That said, aside from drastic cases, where high stress causes a person to go grey fairly quickly, it is often difficult to say whether grey hairs are appearing because of age, stress, or a combination of both

The textbooks describe a clear hierarchy of approaches: Steps that begin with general dental care: Prompt biopsy of any suspicious pigmented oral lesion, with histopathological examination and immunohistochemistry (S-100, HMB-45, SOX10, MART-1) to confirm the diagnosis