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In local synovial tissues, the hypoxic environment favors stable expression of HIF-1, enhancing the survival of pathogenic CD4 + T cell and further aggravating inflammation (141, 151)

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62 An umbrella review of nonpharmacological interventions for neuropsychiatric symptoms of dementia in residential aged care settings reported that tailored interventions that included music and social elements appeared to be most beneficial for depressive symptoms and mood