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Amino Acids 51:3948 Nakatani S, Mano H, Sampei C et al (2009) Chondroprotective effect of the bioactive peptide prolyl-hydroxyproline in mouse articular cartilage in vitro and in vivo

You should avoid self-starting Ipamorelin if you are pregnant, breastfeeding, have a history of cancer, have uncontrolled diabetes, have untreated hormone disorders, have severe fluid retention, or have unexplained symptoms that have not been evaluated

But theres a pattern to who tends to seek it out and who may be a reasonable candidate after a proper evaluation