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However, NAC demonstrates similar biological effects under normal culture conditions (Yamada et al., 2013

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Conversely, certain metabolites, such as secondary bile acids and trimethylamine N-oxide (TMAO), have been implicated in processes associated with DNA damage, genomic instability, and angiogenesis, fostering an environment conducive to carcinogenesis [31,32]

Potent retinoids may also need timing separation, though some users successfully alternate these ingredients on different evenings