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L.ZhangX.KhoshoueiM.ClydesdaleL.BelousoffM

Endogenous iron deposition can be found following breakdown of blood cells (hemolytic event)

In macrophages isolated from mouse myocardium after infarction and in bone marrow-derived macrophages (BMDMs) exposed to ACs in vitro, the concentration of intracellular fatty acids and mitochondrial oxygen consumption upregulated -oxidation and OXPHOS, leading to the generation of NAD+ and promoting the activation of SIRT1 (a sirtuin) that targets PPAR activity and genes related to mitochondrial biogenesis [71, 72]

11,14 NAFLD patients who also have type 2 diabetes mellitus have the highest risk of cirrhosis and liver failure