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How it Works: It achieves skin lightening by reducing the overall production of melanin (skin pigment) and actively promoting the conversion of darker Eumelanin to lighter Pheomelanin

In July 2021, the FDA issued Ardelyx a Complete Response Letter in which it stated that the molecules effect size was small and of unclear clinical significance. Then, in November 2022, an FDA advisory committee voted 9-4 that Xphozahs benefits outweighed its risks

doi: 10.1161/CIRCULATIONAHA.112.000434 41 BosschaertsTGuilliamsMStijlemansBMoriasYEngelDTackeFet al

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