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Ongoing studies continue to monitor for potential rare side effects, including effects on the pancreas, thyroid, and cardiovascular system

Some people find sublingual administration more familiar or comfortable

This means there are both weight-dependent and weight-independent effects on the heart. The level of benefit in the study is close to what was observed in another trial, SELECT, which looked at reductions in heart events in people taking semaglutide for weight loss

If patients develop right upper quadrant pain, especially with fever or jaundice, prompt evaluation including abdominal ultrasound is recommended to assess for gallbladder disease, a known risk with tirzepatide therapy