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At the 24-week mark, the mean increases in heart rate were: 1 mg dose: +4.1 bpm 4 mg dose: +6.1 bpm 8 mg dose: +7.9 bpm 12 mg dose: +7.8 bpm These increases were observed to be maximal around 24 weeks and then showed a slight attenuation, though they remained elevated above baseline for the entire 48-week study period

A new study analyzing over 215,000 GLP-1 users reveals patterns that extend far beyond weight metrics

STEP and SURMOUNT collected adverse event data but didnt systematically track menstrual changes

Mechanistic Links Between GLP-1 RAs and Thyroid Neoplasms GLP-1 receptor effects on thyroid tissue originate from GLP-1 receptors present on thyroid cells