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With rising concentrations of KA, the K m values of the monophenolase activity increased and the V max values decreased, an indication of a mixed mode of inhibition, with an inhibition constant K I of 1.1 M and K IS of 61 M

Subsequently, phosphorylated Smad3 bound to Smad4 (the partner Smad) and was transported from the cytoplasm to the nucleus to activate the transcription of downstream target genes related to ANP and -MHC (96)