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7 Achieving the best possible outcomessignificant, sustainable weight loss and improved well-beingrequires a partnership between the medication and positive lifestyle changes, particularly concerning diet and exercise

However, few prospective studies have conducted prespecified, systematic causal pathway analyses linking these metabolic improvements to reproductive endpoints such as ovulation, clinical pregnancy, or live birth rates

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270,271 GLP-1 or exendin-4 treatment of cultured rat embryonic cerebral cortical cells promoted cell survival during hypoxic injury, and this effect was blocked by GLP-1R antagonists and not seen in GLP-1R knockout mice