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Caffeine protects against experimental acute pancreatitis by inhibition of inositol 1,4,5-trisphosphate receptor-mediated Ca2+ release

Interestingly, in a study in thyroid cancer, ROS-dependent inhibition of MAPK/ERK and PI3K/AKT pathways has been shown to mediate cancer cytotoxicity in vivo [49]

Comparative Pharmacology Comparisons against structurally similar peptides including longer-acting analogues, fragment peptides, and chemically modified variants help contextualize a given experiment

PMID: Summary Keywords GLP-1 receptor (GLP-1R), metabolic dysfunction, Mitochondria-ER Contact Sites (MERCS), signalosomes, GLP1 receptor agonist (GLP1-RAs) Citation Cruz P, Puebla-Huerta A, Troncoso MF, Silva-Pavez E, Hidalgo-Fadic Y and Ahumada-Castro U (2026) GLP-1 receptor and Mitochondria-ER Contact Sites: an emerging mechanism of metabolic regulation