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This review summarizes the bidirectional regulatory mechanisms of the brain-bone axis, including descending pathways (such as the regulation of bone metabolism by the sympathetic nervous system, parasympathetic nervous system, and hypothalamic nuclei) and ascending feedback (such as bone-derived factors influencing central nervous system function through the blood-brain barrier), and explores the synergistic roles of endocrine systems (such as the thyroid axis and gonadal axis) within this network

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Coffea arabica Coffea arabica or coffee plant is composed of several essential phytochemicals including polyphenols

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