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Across registered trials, retatrutide has produced the largest weight reductions reported for an incretin-class compound roughly 24% at 12 mg over 48 weeks in phase 2 [1], extended to about 2829% over 6880 weeks in the phase 3 TRIUMPH topline [5], alongside lower HbA1c in type 2 diabetes and large falls in liver-fat content

By reducing somatostatin, ipamorelin is able to raise levels of endogenous GH and IGF-1 on par with what is possible with exogenous GH therapy [3]

doi: 10.1111/cns.14130 32 ZhangYHuangRChengMWangLChaoJLiJet al