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Oral GLP-1 agonists are showing promise in Phase 3 clinical trials, with Novo Nordisk reporting oral semaglutide results in a mean weight loss of 15.1% over 68 weeks 7 , and Eli Lilly reporting their own oral GLP-1 receptor agonist, Orforglipron, resulting in 14.7% weight loss over 36 weeks 8

FLOW Trial Committees and Investigators PMID: 38785209 Introduction Traditionally, and rightly so, the care of patients with chronic kidney disease (CKD) is centered around approaches that slow disease progression

Urbina et al

As circulating carnitine levels increase following an oral dose, the kidneys rapidly decrease their reabsorption efficiency and increase renal clearance