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Data from clinical trials show A1C reductions of 12% when combining these agents, though individual responses vary based on baseline insulin secretion capacity, beta-cell function, and genetic factors influencing GLP-1R expression

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When to pause or reverse the taper Red flags that should pause your taper include weight gain exceeding 3% of your lowest weight, significant increase in hunger that interferes with daily functioning, worsening metabolic markers such as rising blood sugar, blood pressure, or lipid levels, return of binge eating patterns or loss-of-control eating episodes, and significant emotional distress related to appetite changes