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(3) removing Fmoc protecting groups, and sequentially coupling by coupling Fmoc or Boc protected alpha amino acid or peptide segments according to the sequence of semaglutide and then removing the Fmoc protecting groups, wherein the coupling sequence of the Fmoc or Boc protected alpha amino acid is as follows: Fmoc-Arg (Pbf) -OH, Fmoc-Gly-OH, Fmoc-Arg (Pbf) -OH, Fmoc-Val-OH, Fmoc-Leu-OH, Fmoc-Trp (Boc) -OH, Fmoc-Ala-OH, Fmoc-Ile-OH, Fmoc-Phe-OH, Fmoc-Glu (OtBu) -OH, Fmoc-Lys (Alloc) -OH, Fmoc-Ala-OH, Fmoc-Gln (Trt) -OH, Fmoc-Gly-OH, Fmoc-Glu (OtBu) -OH, Fmoc-Leu-OH, Fmoc-Tyr (tBu) -OH, Fmoc-Ser (tBu) -OH (Fmoc-Ser (tBu) -OH, Fmoc-Val-OH, Fmoc-OtBu (Asp), (Asp, Fmoc-Val) -OH, Fmoc-Leu-OH, Fmoc-Leu-Asp (Ser-Leu) -OH, Fmoc-Leu-OH, Fmoc-Ser (Ser-Leu) -OH, Fmoc-Gly-Leu-OH, Fmoc-Gly-OH, Fmoc-Ser (Ser-OH, Fmoc-Gly-OH, Fmoc-Gly-Ser-Leu-OH, Fmoc-Ser-OH, Fmoc-Ser-OH, etc, Fmoc-Thr (tBu) -OH, Fmoc-Phe-OH, Fmoc-Thr (tBu) -OH, Fmoc-Gly-OH, Fmoc-Glu (OtBu) -OH, Fmoc-Aib-OH, Boc-His (Trt) -OH

Sllsten G, Kreku S, Unosson H

Understanding this difference is key to discussing your treatment options with your doctor or pharmacist