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That rapid destruction is why researchers spent decades trying to engineer a version that would last longer

Hsdb 1405 123

Patients were excluded if they had a major cardiovascular event within the last 60 days, type 1 diabetes mellitus, history of pancreatitis, or a history of severe hypoglycemia

Four alanine mutated residues, V229A, V160A, I165A, and L401A, caused a significant decrease in GLP-1R internalisation versus WT receptor, with GLP-1R V229A and V160A causing a 40%, and I165A and L401A a 30% decrease in internalisation (Figure 2H, bottom graph)