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M1 is further metabolized to M2 by one or several cytosolic enzymes

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Parkinsonism Relat Disord 79:e85-86 Hauser RA, Olanow CW, Dzyngel B, Bilbault T, Shill H, Isaacson S, Dubow J, Agro A (2016) Sublingual apomorphine (APL-130277) for the acute conversion of OFF to ON in Parkinsons disease