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Each member of the treatment groups received an icv injection of scopolamine hydrobromide (70 nmof in 2 aCSF over a duration of 20 s) 20 min prior to testing followed by Dihexa (300 pmol in 2 aCSF), Hinge (300 pmol in 2 aCSF), or Hinge + Dihexa (300 pmol in 4 aCSF) 5 min prior to testing

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A smaller pilot study also revealed that cerebral glucose delivery was determined by plasma glucose concentration and cerebral blood flow, with injured brains exhibiting less glucose uptake and utilization around lesions but increased utilization at distal hyperglycolytic sites in the brain [32]