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Nat Rev Neurosci 22:290307

IshiiMShibataRKondoKKambaraTShimizuYTanigawaTet al

Initial results reported that phase I metabolism of the nootropic was very low with an intrinsic clearance of 2.72 ul/min/mg, as well as an average half life of approximately 510 minutes

After this, patients applied a moisturizer containing these four active ingredients to one side of the face and a placebo to the other side twice daily for 12 weeks