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The Modern Problem: Light Deprivation In modern societies, several trends are reducing our exposure to natural sunlight: More time spent indoors Widespread use of LED lights, which emit no infrared light Low-E glass in buildings blocks beneficial wavelengths A new Department of Energy ruling (set for 2028) may further restrict the sale of bulbs with any infrared component due to energy efficiency requirements

Chen found in human melanoma cells that silencing iPLA2 would enhance the sensitivity to p53-mediated ferroptosis without significant effects on cells that usually express iPLA2, suggesting that iPLA2 can inhibit p53-mediated ferroptosis, and p53-driven ferroptosis is independent of GPX4 [41]

doi: 10.3390/nu14183705