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By respecting the RUO mandate, researchers protect themselves, operate within the legal framework of scientific discovery, and contribute responsibly to their field

Although the magnitude of hydraulic resistance experienced by migrating breast cancer cells in vivo is currently unknown, mathematical modeling indicates that depending on the interstitial fluid viscosity and matrix permeability, the hydraulic resistance within 3D matrices could potentially match or even exceed that observed in microchannels [50, 203]

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Traumatic Brain Injury Preliminary studies suggest potential benefits in traumatic brain injury models, with reduced inflammation and improved neurological outcomes