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Excessive production of ROS, largely arising from mitochondrial oxidative phosphorylation, is a major driver of oxidative damage and mitochondrial dysfunction processes that correlate with MDD symptom severity, illness chronicity, cognitive impairment, and poor antidepressant response [138, 139]

Martin BD, Finke RG

Life in extreme environments

However, you can experience a different outcome when an external change is made, such as supplementing with methylated B vitamins and cleaning up your genes function